Functional characterisation of obesity-associated variants involving the alpha and beta isoforms of human SH2B1
نویسندگان
چکیده
Laura R. Pearce#, Ray Joe#, Michael E. Doche, Hsiao-Wen Su, Julia M. Keogh, Elana Henning, Lawrence S. Argetsinger, Elena G. Bochukova, Joel M. Cline, Sumedha Garg, Sadia Saeed, Steven Shoelson, Stephen O’Rahilly, Inês Barroso, Liangyou Rui, I. Sadaf Farooqi#, and Christin Carter-Su# University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK; Graduate Program in Cellular and Molecular Biology, Department of Molecular and Integrative Physiology, Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, U.S.A., Joslin Diabetes Center and Department of Medicine, Harvard University, Boston, MA 02115,Wellcome Trust Sanger Institute, Hinxton, UK. Brief Report:
منابع مشابه
Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.
SH2B1 (previously named SH2-B), a cytoplasmic adaptor protein, binds via its Src homology 2 (SH2) domain to a variety of protein tyrosine kinases, including JAK2 and the insulin receptor. SH2B1-deficient mice are obese and diabetic. Here we demonstrated that multiple isoforms of SH2B1 (alpha, beta, gamma, and/or delta) were expressed in numerous tissues, including the brain, hypothalamus, liver...
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